This is an opportunity for the right individual to join a small dynamic team and help review and revise the DMPK strategy for projects from Hit ID to Candidate Selection. We are looking for a motivated individual with a track record of success in producing candidate drugs. You will report to the VP Drug Discovery, DMPK. You will be expected to engage fully within the department with DMPK modelling and clinical pharmacology colleagues, and within projects in multi-functional collaborations, including Computational Chemistry, to support profiling of compounds, building a clear picture of IVIVC PK/PD, and ultimately to support the identification and progression of drug candidates.

• As a leader you will provide leadership and development for a team of project reps. Responsible for their technical and personal development, leading on strategy and providing a clear direction.
• As an expert within the department, you will work closely with later stage reps and modelling colleagues to develop and execute effective non clinical PK/PD strategies from early discovery through to development, ultimately delivering robust human PK and dose prediction strategies for all pipeline projects.
• As a project rep, you will lead DMPK strategy, be accountable for study design, influencing screening cascades, providing clear interpretation and communication of DMPK data and recommendations to drug discovery project teams to aid effective drug design and risk mitigation.
• Working with other functional project reps to align on translational strategy, you will be responsible for delivering robust IVIVC strategies, providing solutions to scaling problems, and actively drive biomarker and target engagement initiatives.
• Take responsibility for DMPK plans within projects
• Development, implement and communicate DMPK strategy for the wider DMPK organisation
• You will have the opportunity to work within the wider drug discovery group, providing input across all stages of the pipeline

• Excellent communication skills, able to collaborate with internal and external colleagues, and influence change. Able to communicate strategy and technical material to a variety of audiences.
• Strong leadership skills, experienced in developing staff, willing to share knowledge with less experienced members of the team through mentoring or line management.
• Ideally experienced in candidate profiling for LO, preclinical and clinical development, with proven problem solving and critical thinking skills.
• Experience in determination and interpretation of ADME properties, IVIVC, human dose prediction, understanding of PBPK, calculation of safety margins, able to adapt study designs.
• Up to date knowledge of industry practice and regulatory guidance, including MIST guidelines.
• As a key contributor within a cross functional team you should be comfortable working in a fast paced, dynamic environment and on multiple projects with changing priorities and deadlines
• Experience with Phoenix ( experience with PBPK modelling packages would be a bonus), familiar with QSP and model based approaches to drug development.